Your browser doesn't support javascript.
loading
ZNF671 methylation test in cervical scrapings for cervical intraepithelial neoplasia grade 3 and cervical cancer detection.
Zhu, Peng; Xiong, Jing; Yuan, Ding; Li, Xiang; Luo, Lili; Huang, Ju; Wang, Binbin; Nie, Quanfang; Wang, Shuli; Dang, Liying; Chen, Yan; Li, Shu; An, Yuhang; Yang, Li; Liu, Rong; He, Yanping; Li, Xiong; Chen, Puxiang; Zhou, Honghao; Li, Qing.
Afiliación
  • Zhu P; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, P.R. China; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, 110 Xiangya Road, Changsha 410078, P.R. China; Engineering Research C
  • Xiong J; Department of Gynaecology and Obstetrics, The Second Xiangya Hospital, Central South University, 139 Renming Road, Changsha 410011, P.R. China.
  • Yuan D; Health Management Center, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, P.R. China.
  • Li X; Department of Gynaecology, The Third Xiangya Hospital, Central South University, 138 Tongzipo Road, Changsha 410013, P.R. China.
  • Luo L; Department of Gynaecology, The First Affiliated Hospital of Shantou University Medical College, Shantou, P.R. China.
  • Huang J; Department of Gynaecology, The First Affiliated Hospital of Shantou University Medical College, Shantou, P.R. China.
  • Wang B; Department of Obstetrics and Gynecology, Loudi Central Hospital, 51 Chang Qing Road, Loudi 417000, P.R. China.
  • Nie Q; Department of Obstetrics and Gynecology, Loudi Central Hospital, 51 Chang Qing Road, Loudi 417000, P.R. China.
  • Wang S; Department of Obstetrics and Gynecology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450000, P.R. China.
  • Dang L; Department of Obstetrics and Gynecology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450000, P.R. China.
  • Chen Y; Xiangya Medical Laboratory, Central South University, 110 Xiangya Road, Changsha 410078, P.R. China.
  • Li S; Xiangya Medical Laboratory, Central South University, 110 Xiangya Road, Changsha 410078, P.R. China.
  • An Y; Xiangya Medical Laboratory, Central South University, 110 Xiangya Road, Changsha 410078, P.R. China.
  • Yang L; Xiangya Medical Laboratory, Central South University, 110 Xiangya Road, Changsha 410078, P.R. China.
  • Liu R; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, P.R. China; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, 110 Xiangya Road, Changsha 410078, P.R. China; Engineering Research C
  • He Y; Key Specialty of Clinical Pharmacy, The First Affiliated Hospital, Guangdong Pharmaceutical University, 19 Nonglinxia Road, Yuexiu District, Guangzhou, Guangdong, P.R. China.
  • Li X; Key Specialty of Clinical Pharmacy, The First Affiliated Hospital, Guangdong Pharmaceutical University, 19 Nonglinxia Road, Yuexiu District, Guangzhou, Guangdong, P.R. China.
  • Chen P; Department of Gynaecology and Obstetrics, The Second Xiangya Hospital, Central South University, 139 Renming Road, Changsha 410011, P.R. China.
  • Zhou H; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, P.R. China; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, 110 Xiangya Road, Changsha 410078, P.R. China; Engineering Research C
  • Li Q; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, P.R. China; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, 110 Xiangya Road, Changsha 410078, P.R. China; Engineering Research C
Cell Rep Med ; 4(8): 101143, 2023 08 15.
Article en En | MEDLINE | ID: mdl-37557178
ABSTRACT
Effective triage of high-risk human papillomavirus (hrHPV)+ women is warranted to avoid unnecessary referral and overtreatment. Molecular triage tests have recently begun to impact cervical intraepithelial neoplasia grade 3 (CIN3) or cervical cancer (CC), termed CIN3+, detection. We find that zinc finger protein 671 methylation (ZNF671m) test has superior performance for CIN3+ detection in all single molecular triage tests, including HPV16/18 genotyping, paired box gene 1 methylation (PAX1m), and ZNF671m, in the training set. Using ZNF671m test instead of Thinprep cytologic test (TCT) as a single triage strategy or as a combined triage strategy with HPV16/18 genotyping has achieved comparable sensitivity but higher specificity for CIN3+ detection among 391 hrHPV+ women in the validation set. Little attention has been paid to the women with hrHPV- status but detected CIN3+. We find that the CIN3+ risk after a negative result could be reduced further by triage using ZNF671m in hrHPV- patients.
Asunto(s)
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Displasia del Cuello del Útero / Neoplasias del Cuello Uterino Tipo de estudio: Diagnostic_studies Idioma: En Revista: Cell Rep Med Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Displasia del Cuello del Útero / Neoplasias del Cuello Uterino Tipo de estudio: Diagnostic_studies Idioma: En Revista: Cell Rep Med Año: 2023 Tipo del documento: Article