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Pre-Operative SARS-CoV-2 Testing in Asymptomatic Heart Transplantation Recipients.
Zwetsloot, Peter-Paul; Smit, Wouter L; Van der Kaaij, Niels P; Szymanski, Mariusz K; Van der Meer, Manon G; Van Laake, Linda W; Troelstra, Annet; Wegdam-Blans, Marjolijn C A; Oerlemans, Marish I F J.
Afiliación
  • Zwetsloot PP; Department of Cardiology, University Medical Centre Utrecht, 3584 CX Utrecht, The Netherlands.
  • Smit WL; Department of Medical Microbiology, University Medical Centre Utrecht, 3584 CX Utrecht, The Netherlands.
  • Van der Kaaij NP; Department of Cardiothoracic Surgery, University Medical Centre Utrecht, 3584 CX Utrecht, The Netherlands.
  • Szymanski MK; Department of Cardiology, University Medical Centre Utrecht, 3584 CX Utrecht, The Netherlands.
  • Van der Meer MG; Department of Cardiology, University Medical Centre Utrecht, 3584 CX Utrecht, The Netherlands.
  • Van Laake LW; Department of Cardiology, University Medical Centre Utrecht, 3584 CX Utrecht, The Netherlands.
  • Troelstra A; Department of Medical Microbiology, University Medical Centre Utrecht, 3584 CX Utrecht, The Netherlands.
  • Wegdam-Blans MCA; Department of Medical Microbiology, University Medical Centre Utrecht, 3584 CX Utrecht, The Netherlands.
  • Oerlemans MIFJ; Department of Cardiology, University Medical Centre Utrecht, 3584 CX Utrecht, The Netherlands.
Biomedicines ; 11(8)2023 Jul 26.
Article en En | MEDLINE | ID: mdl-37626599
ABSTRACT

INTRODUCTION:

From the start of the coronavirus disease 2019 (COVID-19) pandemic, international guidelines have recommended pre-operative screening for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) before heart transplantation (HTx). Due to the changing prevalence of COVID-19, the chances of false positive results have increased. Because of increased immunity in the population and evolution of SARS-CoV-2 to current Omicron variants, associated mortality and morbidity have decreased. We set out to investigate the yield and side effects of SARS-CoV-2 screening in our center.

METHODS:

We performed a retrospective cohort study in the University Medical Center Utrecht. The study period was from March 2019 to January 2023. All data from patients who underwent HTx were collected, including all pre-operative and post-operative SARS-CoV-2 tests. Furthermore, all clinical SARS-CoV-2 tests for the indication of potential HTx were screened.

RESULTS:

In the period under study, 51 patients underwent HTx. None of the recipients reported any symptoms of a viral infection. Fifty HTx recipients were screened for SARS-CoV-2. Forty-nine out of fifty patients tested negative. One patient had a false positive result, potentially delaying the HTx procedure. There were no cancelled HTx procedures due to a true positive SARS-CoV-2 test result.

CONCLUSION:

Pre-operative SARS-CoV-2 screening in asymptomatic HTx recipients did not lead to any true positive cases. In 2% of the cases, screening resulted in a false positive test result. With the current Omicron variants, in combination with a low-prevalence situation, we propose to abandon pre-operative SARS-CoV-2 screening and initiate a symptom-driven approach for the general viral testing of patients who are called in for a potential HTx.
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Texto completo: 1 Base de datos: MEDLINE Tipo de estudio: Guideline / Observational_studies / Risk_factors_studies Idioma: En Revista: Biomedicines Año: 2023 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Tipo de estudio: Guideline / Observational_studies / Risk_factors_studies Idioma: En Revista: Biomedicines Año: 2023 Tipo del documento: Article