Salviamilthone A-O, diterpenoid quinones from Salvia miltiorrhiza.
Phytochemistry
; 215: 113840, 2023 Nov.
Article
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| MEDLINE
| ID: mdl-37648044
ABSTRACT
Fifteen undescribed diterpenoid quinones salviamilthone A-O (1-15), together with three known diterpenoid quinones (16-18), were isolated from the roots of Salvia miltiorrhiza Bunge. Their structures were elucidated using 1D and 2D NMR data, while the relative and absolute configurations were confirmed by NOESY correlations and comparison between experimental and calculated ECD spectra. In the evaluation of bioactivities, salviamilthone J (10), salviamone (18) (10 µM) significantly increased cell viability and decreased the expression of IL-1ß in lipopolysaccharide-induced BEAS-2B cells. These data provide the molecular justification for the usage of Salvia miltiorrhiza in treating acute lung injury.
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Base de datos:
MEDLINE
Asunto principal:
Salvia
/
Salvia miltiorrhiza
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Diterpenos
Idioma:
En
Revista:
Phytochemistry
Año:
2023
Tipo del documento:
Article