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KRASG12D inhibition in pancreatic cancer: Fas expression facilitates immune clearance.
Yeh, Celine; Park, Wungki; Yaeger, Rona.
Afiliación
  • Yeh C; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Park W; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA; David M. Rubenstein Center for Pancreatic Cancer Research, New York, NY 10065, USA.
  • Yaeger R; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address: yaegerr@mskcc.org.
Dev Cell ; 58(17): 1515-1516, 2023 09 11.
Article en En | MEDLINE | ID: mdl-37699334
ABSTRACT
In an article in this issue of Developmental Cell and in a second paper in Cancer Cell, Mahadevan et al. demonstrate that KrasG12D suppression remodels the immunosuppressive microenvironment of KrasG12D pancreatic cancers, recruits activated CD8+ cytotoxic T cells, and epigenetically upregulates Fas expression in cancer cells, leading to tumor clearance via Fas/FasL-mediated apoptosis.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Proteínas Proto-Oncogénicas p21(ras) Idioma: En Revista: Dev Cell Asunto de la revista: EMBRIOLOGIA Año: 2023 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Proteínas Proto-Oncogénicas p21(ras) Idioma: En Revista: Dev Cell Asunto de la revista: EMBRIOLOGIA Año: 2023 Tipo del documento: Article