Scaling the EVERREST of severe, early-onset fetal growth restriction.
J Clin Invest
; 133(18)2023 09 15.
Article
en En
| MEDLINE
| ID: mdl-37712422
ABSTRACT
Severe, early-onset fetal growth restriction is a leading cause of medically indicated preterm birth and substantially increases the risk for perinatal death or disability. No treatments exist to improve fetal growth or safely prolong pregnancy. Furthermore, wide-ranging phenotypes limit the accurate prediction of pregnancy outcome. In this issue of the JCI, Spencer and colleagues combine a discovery-science approach with ultrasound parameters to identify the most discriminative models for predicting either the primary outcome of fetal or neonatal death, or a secondary outcome of death or delivery at 28 weeks of gestation or earlier. Their findings can better individualize patient counseling but, just as compellingly, provide the capacity to identify those pregnancies that are at such considerable risk as to justify enrollment in paradigm-shifting interventional trials that are in the pipeline.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Nacimiento Prematuro
/
Retardo del Crecimiento Fetal
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
J Clin Invest
Año:
2023
Tipo del documento:
Article