Beclin1 is essential for the pancreas development.
Dev Biol
; 504: 113-119, 2023 12.
Article
en En
| MEDLINE
| ID: mdl-37739117
ABSTRACT
Beclin1 (Becn1) is a multifunctional protein involved in autophagy regulation, membrane trafficking, and tumor suppression. In this study, we examined the roles of Becn1 in the pancreas development by generating mice with conditional deletion of Becn1 in the pancreas using pancreatic transcriptional factor 1a (Ptf1a)-Cre mice (Becn1f/f; Ptf1aCre/+). Surprisingly, loss of Becn1 in the pancreas resulted in severe pancreatic developmental defects, leading to insufficient exocrine and endocrine pancreatic function. Approximately half of Becn1f/f; Ptf1aCre/+ mice died immediately after birth. However, duodenum and neural tissue development were almost normal, indicating that pancreatic insufficiency was the cause of death. These findings demonstrated a novel role for Becn1 in pancreas morphogenesis, differentiation, and growth, and suggested that loss of this factor leaded to pancreatic agenesis at birth.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Páncreas
/
Regulación del Desarrollo de la Expresión Génica
Idioma:
En
Revista:
Dev Biol
Año:
2023
Tipo del documento:
Article