Real-world practice of estrogen and progestogen prescriptions in menopausal women in Japan: A descriptive study using a Japanese claims database.
J Obstet Gynaecol Res
; 49(12): 2952-2961, 2023 Dec.
Article
en En
| MEDLINE
| ID: mdl-37752731
ABSTRACT
AIM:
This study aimed to investigate the real-world clinical practice of estrogen and progestogen prescriptions for menopausal women.METHODS:
Using a health care database in Japan, we conducted a cross-sectional study on estrogen prescriptions and detailed analyses of newly initiated estrogens and concomitant prescriptions of progestogens. Data between January 2005 and December 2021 were analyzed.RESULTS:
In 2021, the proportion of women aged 45-49 years receiving estrogens was 25.8 [95% confidence interval (CI) 25.3, 26.3] per 1000 women, while it was 6.4 [95% CI 6.0, 6.7] for those aged ≥60 years. The prescription of estrogens gradually increased in women aged 50-59 years after 2009. In women without a history of hysterectomy, transdermal estradiol was the primary form of estrogens prescribed for ≥180 days, in women aged <60 years. The proportion of transdermal estradiol gradually increased each year, whereas that of oral-conjugated equine estrogens decreased. Among progestogen, the proportions of dydrogesterone and transdermal norethisterone acetate increased over time, while that of medroxyprogesterone acetate decreased. Approximately 30% of women prescribed estrogens for ≥180 days did not initiate progestogen concurrently. In women undergoing hysterectomy, progestogen was not initiated in >90% of cases, and transdermal estradiol was prescribed in approximately 80% of cases in 2021.CONCLUSIONS:
This study reviewed the prescription of estrogens in menopausal women in Japan. A considerable number of women with a uterus are receiving estrogen therapy rather than estrogen-progestogen therapy (EPT), despite the guidelines recommending the use of EPT in these women.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Progestinas
/
Pueblos del Este de Asia
Tipo de estudio:
Guideline
/
Observational_studies
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Obstet Gynaecol Res
Asunto de la revista:
GINECOLOGIA
/
OBSTETRICIA
Año:
2023
Tipo del documento:
Article