Genomic epidemiology reveals multidrug resistant plasmid spread between Vibrio cholerae lineages in Yemen.
Nat Microbiol
; 8(10): 1787-1798, 2023 10.
Article
en En
| MEDLINE
| ID: mdl-37770747
ABSTRACT
Since 2016, Yemen has been experiencing the largest cholera outbreak in modern history. Multidrug resistance (MDR) emerged among Vibrio cholerae isolates from cholera patients in 2018. Here, to characterize circulating genotypes, we analysed 260 isolates sampled in Yemen between 2018 and 2019. Eighty-four percent of V. cholerae isolates were serogroup O1 belonging to the seventh pandemic El Tor (7PET) lineage, sub-lineage T13, whereas 16% were non-toxigenic, from divergent non-7PET lineages. Treatment of severe cholera with macrolides between 2016 and 2019 coincided with the emergence and dominance of T13 subclones carrying an incompatibility type C (IncC) plasmid harbouring an MDR pseudo-compound transposon. MDR plasmid detection also in endemic non-7PET V. cholerae lineages suggested genetic exchange with 7PET epidemic strains. Stable co-occurrence of the IncC plasmid with the SXT family of integrative and conjugative element in the 7PET background has major implications for cholera control, highlighting the importance of genomic epidemiological surveillance to limit MDR spread.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Cólera
/
Vibrio cholerae O1
Tipo de estudio:
Screening_studies
País/Región como asunto:
Asia
Idioma:
En
Revista:
Nat Microbiol
Año:
2023
Tipo del documento:
Article