3, 3'-diindolylmethane, a natural aryl hydrocarbon receptor agonist, alleviates ulcerative colitis by enhancing "glycolysis-lactate-STAT3â³ and TIP60 signals-mediated Treg differentiation.

Liu, Shukun; Yan, Wenxin; Lv, Qi; Yang, Ling; Miao, Yumeng; Hu, Yuxiao; Wei, Zhifeng

3, 3'-diindolylmethane, a natural aryl hydrocarbon receptor agonist, alleviates ulcerative colitis by enhancing "glycolysis-lactate-STAT3â³ and TIP60 signals-mediated Treg differentiation.

Liu, Shukun; Yan, Wenxin; Lv, Qi; Yang, Ling; Miao, Yumeng; Hu, Yuxiao; Wei, Zhifeng.

Afiliación

Liu S; Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China.
Yan W; Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China.
Lv Q; Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China.
Yang L; Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China.
Miao Y; Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China.
Hu Y; Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China.
Wei Z; Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China. Electronic address: 1020132346@cpu.edu.cn.

Mol Immunol ; 163: 147-162, 2023 11.

Article en En | MEDLINE | ID: mdl-37793204

Asunto(s)

Colitis Ulcerosa; Colitis; Receptores de Hidrocarburo de Aril; Animales; Ratones; Diferenciación Celular; Colitis/inducido químicamente; Colitis/tratamiento farmacológico; Colitis/metabolismo; Colitis Ulcerosa/tratamiento farmacológico; Factores de Transcripción Forkhead/metabolismo; Glucosa/metabolismo; Glucólisis; Hipoxia/metabolismo; Interleucina-10/metabolismo; Ácido Láctico/metabolismo; Ácido Láctico/farmacología; Receptores de Hidrocarburo de Aril/agonistas; Linfocitos T Reguladores/efectos de los fármacos; Linfocitos T Reguladores/metabolismo; Células Th17; Factor de Transcripción STAT3/efectos de los fármacos; Factor de Transcripción STAT3/metabolismo; Lisina Acetiltransferasa 5/efectos de los fármacos; Lisina Acetiltransferasa 5/metabolismo

Palabras clave

3, 3'-diindolylmethane; Aryl hydrocarbon receptor; Glycolysis; TIP60; Treg cells; Ulcerative colitis

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Colitis Ulcerosa / Receptores de Hidrocarburo de Aril / Colitis Tipo de estudio: Prognostic_studies Idioma: En Revista: Mol Immunol Año: 2023 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google