Molecular Pathways in the Pathogenesis of Systemic Juvenile Idiopathic Arthritis.
Rheum Dis Clin North Am
; 49(4): 895-911, 2023 11.
Article
en En
| MEDLINE
| ID: mdl-37821202
Systemic juvenile idiopathic arthritis (sJIA) is a rare childhood chronic inflammatory disorder with risk for life-threatening complications including macrophage activation syndrome and lung disease. At onset, sJIA pathogenesis resembles that of the autoinflammatory periodic fever syndromes with marked innate immune activation, expansion of neutrophils and monocytes, and high levels of interleukin-18. Here, we review the current conceptual understanding of sJIA pathogenesis with a focus on both innate and adaptive immune pathways. Finally, we consider how recent progress toward understanding the immunologic basis of sJIA may support new therapies for refractory disease courses.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Artritis Juvenil
/
Síndrome de Activación Macrofágica
Tipo de estudio:
Etiology_studies
Idioma:
En
Revista:
Rheum Dis Clin North Am
Asunto de la revista:
REUMATOLOGIA
Año:
2023
Tipo del documento:
Article