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An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function.
Cuesta-Hernández, Hipólito Nicolás; Contreras, Julia; Soriano-Maldonado, Pablo; Sánchez-Wandelmer, Jana; Yeung, Wayland; Martín-Hurtado, Ana; Muñoz, Inés G; Kannan, Natarajan; Llimargas, Marta; Muñoz, Javier; Plaza-Menacho, Iván.
Afiliación
  • Cuesta-Hernández HN; Kinases, Protein Phosphorylation and Cancer Group, Structural Biology Programme, Spanish National Cancer Research Center (CNIO), C/Melchor Fernández Almagro num. 3, 28029, Madrid, Spain.
  • Contreras J; Kinases, Protein Phosphorylation and Cancer Group, Structural Biology Programme, Spanish National Cancer Research Center (CNIO), C/Melchor Fernández Almagro num. 3, 28029, Madrid, Spain.
  • Soriano-Maldonado P; Kinases, Protein Phosphorylation and Cancer Group, Structural Biology Programme, Spanish National Cancer Research Center (CNIO), C/Melchor Fernández Almagro num. 3, 28029, Madrid, Spain.
  • Sánchez-Wandelmer J; Faculty of Experimental Sciences, Universidad Francisco de Vitoria (UFV), 28223, Pozuelo de Alarcón, Madrid, Spain.
  • Yeung W; Proteomics Unit, Spanish National Cancer Research Center (CNIO), C/Melchor Fernández Almagro num. 3, 28029, Madrid, Spain.
  • Martín-Hurtado A; Institute of Bioinformatics, Department of Biochemistry & Molecular Biology, University of Georgia, Athens, GA, 30602, USA.
  • Muñoz IG; Kinases, Protein Phosphorylation and Cancer Group, Structural Biology Programme, Spanish National Cancer Research Center (CNIO), C/Melchor Fernández Almagro num. 3, 28029, Madrid, Spain.
  • Kannan N; Protein Crystallography Unit, Spanish National Cancer Research Center (CNIO), C/Melchor Fernández Almagro num. 3, 28029, Madrid, Spain.
  • Llimargas M; Institute of Bioinformatics, Department of Biochemistry & Molecular Biology, University of Georgia, Athens, GA, 30602, USA.
  • Muñoz J; Institute of Molecular Biology of Barcelona (IMBB) CSIC, 08028, Barcelona, Spain.
  • Plaza-Menacho I; Proteomics Unit, Spanish National Cancer Research Center (CNIO), C/Melchor Fernández Almagro num. 3, 28029, Madrid, Spain.
Nat Commun ; 14(1): 6548, 2023 10 17.
Article en En | MEDLINE | ID: mdl-37848415
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Familia-src Quinasas Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Familia-src Quinasas Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article