STAT6 promoting oxalate crystal deposition-induced renal fibrosis by mediating macrophage-to-myofibroblast transition via inhibiting fatty acid oxidation.

Yuan, Tianhui; Xia, Yuqi; Pan, Shengyu; Li, Bojun; Ye, Zehua; Yan, Xinzhou; Hu, Weimin; Li, Lei; Song, Baofeng; Yu, Weimin; Li, Haoyong; Rao, Ting; Lin, Fangyou; Zhou, Xiangjun; Cheng, Fan

Yuan, Tianhui; Xia, Yuqi; Pan, Shengyu; Li, Bojun; Ye, Zehua; Yan, Xinzhou; Hu, Weimin; Li, Lei; Song, Baofeng; Yu, Weimin; Li, Haoyong; Rao, Ting; Lin, Fangyou; Zhou, Xiangjun; Cheng, Fan.

Afiliación

Yuan T; Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
Xia Y; Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
Pan S; Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
Li B; Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
Ye Z; Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
Yan X; Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
Hu W; Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
Li L; Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
Song B; Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
Yu W; Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
Li H; Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
Rao T; Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
Lin F; Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
Zhou X; Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China. 24816439@qq.com.
Cheng F; Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China. urology1969@aliyun.com.

Inflamm Res ; 72(12): 2111-2126, 2023 Dec.

Article en En | MEDLINE | ID: mdl-37924395

Asunto(s)

Cálculos Renales; Miofibroblastos; Animales; Humanos; Ratones; Oxalato de Calcio/metabolismo; Oxalato de Calcio/farmacología; Ácidos Grasos/metabolismo; Fibrosis; Glioxilatos/metabolismo; Glioxilatos/farmacología; Riñón/patología; Cálculos Renales/metabolismo; Cálculos Renales/patología; Macrófagos/metabolismo; Miofibroblastos/patología; Oxalatos/metabolismo; Oxalatos/farmacología; PPAR alfa/metabolismo; Factor de Transcripción STAT6/genética; Factor de Transcripción STAT6/metabolismo

Palabras clave

Fatty acid oxidation; Macrophage-to-myofibroblast transition; Renal fibrosis; STAT6

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Cálculos Renales / Miofibroblastos Idioma: En Revista: Inflamm Res Asunto de la revista: ALERGIA E IMUNOLOGIA / PATOLOGIA Año: 2023 Tipo del documento: Article

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