Ketogenic Diet Has Moderate Effects on the Fecal Microbiota of Wild-Type Mice.
Nutrients
; 15(21)2023 Oct 31.
Article
en En
| MEDLINE
| ID: mdl-37960282
The ketogenic diet (KD) is a high-fat, low-carbohydrate diet that has been reported to have neuroprotective effects. The health effects of KD might be linked to an altered gut microbiome, which plays a major role in host health, leading to neuroprotective effects via the gut-brain axis. However, results from different studies, most often based on the 16S rRNA gene and metagenome sequencing, have been inconsistent. In this study, we assessed the effect of a 4-week KD compared to a western diet (WD) on the colonic microbiome of female C57Bl/6J mice by analyzing fecal samples using fluorescence in situ hybridization. Our results showed distinct changes in the total number of gut bacteria following the 4-week KD, in addition to changes in the composition of the microbiome. KD-fed mice showed higher absolute numbers of Actinobacteria (especially Bifidobacteria spp.) and lower absolute levels of Proteobacteria, often linked to gut inflammation, in comparison with WD-fed mice. Furthermore, an increased abundance of the typically rare genus Atopobium was observed. These changes may indicate the possible anti-inflammatory effects of the KD. However, since the overall changes in the microbiota seem low, the KD effects might be linked to the differential abundance of only a few key genera in mice.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Actinobacteria
/
Fármacos Neuroprotectores
/
Dieta Cetogénica
/
Microbiota
Idioma:
En
Revista:
Nutrients
Año:
2023
Tipo del documento:
Article