One-Step Synthesis of 3-(Fmoc-amino acid)-3,4-diaminobenzoic Acids.
ACS Omega
; 8(44): 41855-41864, 2023 Nov 07.
Article
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| MEDLINE
| ID: mdl-37970022
A one-step method for synthesizing 3-(Fmoc-amino acid)-3,4-diaminobenzoic acids was used to prepare preloaded diaminobenzoate resin. The coupling of free diaminobenzoic acid and Fmoc-amino acids gave pure products in 40-94% yield without any purification step in addition to precipitation except for histidine. For the proline residue, crude products were collected and used for solid-phase peptide synthesis to give a moderate yield of a pentapeptide. In addition, this method was used to prepare unusual amino acid derivatives, namely, (2-naphthyl) alanine and 6-aminohexanoic acid derivatives, in 50 and 65% yield, respectively.
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ACS Omega
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2023
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Article