TEPCAM: Prediction of T-cell receptor-epitope binding specificity via interpretable deep learning.

Chen, Junwei; Zhao, Bowen; Lin, Shenggeng; Sun, Heqi; Mao, Xueying; Wang, Meng; Chu, Yanyi; Hong, Liang; Wei, Dong-Qing; Li, Min; Xiong, Yi

Chen, Junwei; Zhao, Bowen; Lin, Shenggeng; Sun, Heqi; Mao, Xueying; Wang, Meng; Chu, Yanyi; Hong, Liang; Wei, Dong-Qing; Li, Min; Xiong, Yi.

Afiliación

Chen J; State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Zhao B; State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Lin S; State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Sun H; State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Mao X; State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Wang M; Hunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University, Changsha, China.
Chu Y; Department of Pathology, Stanford University School of Medicine, Standford, California, USA.
Hong L; Institute of Natural Sciences, Shanghai Jiao Tong University, Shanghai, China.
Wei DQ; Artificial Intelligence Biomedical Center, Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai, China.
Li M; State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Xiong Y; Hunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University, Changsha, China.

Protein Sci ; 33(1): e4841, 2024 Jan.

Article en En | MEDLINE | ID: mdl-37983648

Asunto(s)

Aprendizaje Profundo; Linfocitos T; Receptores de Antígenos de Linfocitos T; Unión Proteica; Epítopos de Linfocito T/química

Palabras clave

TCR-epitope binding specificity; convolution; cross-attention; deep learning; model interpretability

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Aprendizaje Profundo Idioma: En Revista: Protein Sci Asunto de la revista: BIOQUIMICA Año: 2024 Tipo del documento: Article

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