Epigenetic downregulation of O<sup>6</sup>-methylguanine-DNA methyltransferase contributes to chronic hexavalent chromium exposure-caused genotoxic effect and cell transformation.

Wang, Zhishan; Liu, Zulong; Wang, Po-Shun; Lin, Hsuan-Pei; Rea, Matthew; Kondo, Kazuya; Yang, Chengfeng

Epigenetic downregulation of O⁶-methylguanine-DNA methyltransferase contributes to chronic hexavalent chromium exposure-caused genotoxic effect and cell transformation.

Wang, Zhishan; Liu, Zulong; Wang, Po-Shun; Lin, Hsuan-Pei; Rea, Matthew; Kondo, Kazuya; Yang, Chengfeng.

Afiliación

Wang Z; Stony Brook Cancer Center, Stony Brook University, Lauterbur Drive, Stony Brook, NY 11794, USA; Department of Pathology, Renaissance School of Medicine, Stony Brook University, 101 Nicolls Road, Stony Brook, NY 11794, USA. Electronic address: Zhishan.wang@stonybrook.edu.
Liu Z; Stony Brook Cancer Center, Stony Brook University, Lauterbur Drive, Stony Brook, NY 11794, USA.
Wang PS; Stony Brook Cancer Center, Stony Brook University, Lauterbur Drive, Stony Brook, NY 11794, USA.
Lin HP; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY 40536, USA.
Rea M; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40536, USA.
Kondo K; Department of Oncological Medical Services, Graduate School of Biomedical Sciences, Tokushima University Graduate School, Tokushima City 770-8509, Japan.
Yang C; Stony Brook Cancer Center, Stony Brook University, Lauterbur Drive, Stony Brook, NY 11794, USA; Department of Pathology, Renaissance School of Medicine, Stony Brook University, 101 Nicolls Road, Stony Brook, NY 11794, USA.

Environ Pollut ; 341: 122978, 2024 Jan 15.

Article en En | MEDLINE | ID: mdl-37995958

Asunto(s)

Neoplasias Pulmonares; O(6)-Metilguanina-ADN Metiltransferasa; Humanos; Regulación hacia Abajo; O(6)-Metilguanina-ADN Metiltransferasa/genética; O(6)-Metilguanina-ADN Metiltransferasa/metabolismo; Transformación Celular Neoplásica/genética; Cromo/toxicidad; Cromo/metabolismo; Carcinogénesis; Daño del ADN; Neoplasias Pulmonares/genética; Epigénesis Genética

Palabras clave

DNA methylation; Epigenetic toxicity; Hexavalent chromium [Cr(VI)]; Histone H3 repressive modification; MGMT; O(6)-methylguanine (O(6)-MeG)

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: O(6)-Metilguanina-ADN Metiltransferasa / Neoplasias Pulmonares Idioma: En Revista: Environ Pollut Asunto de la revista: SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article

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