A Colonic Organoid Model Challenged with the Large Toxins of <i>Clostridioides difficile</i> TcdA and TcdB Exhibit Deregulated Tight Junction Proteins.

Schneemann, Martina; Heils, Lucas; Moos, Verena; Weiß, Franziska; Krug, Susanne M; Weiner, January; Beule, Dieter; Gerhard, Ralf; Schulzke, Jörg-Dieter; Bücker, Roland

A Colonic Organoid Model Challenged with the Large Toxins of Clostridioides difficile TcdA and TcdB Exhibit Deregulated Tight Junction Proteins.

Schneemann, Martina; Heils, Lucas; Moos, Verena; Weiß, Franziska; Krug, Susanne M; Weiner, January; Beule, Dieter; Gerhard, Ralf; Schulzke, Jörg-Dieter; Bücker, Roland.

Afiliación

Schneemann M; Clinical Physiology, Nutritional Medicine, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, 12203 Berlin, Germany.
Heils L; Clinical Physiology, Nutritional Medicine, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, 12203 Berlin, Germany.
Moos V; Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, 12203 Berlin, Germany.
Weiß F; Clinical Physiology, Nutritional Medicine, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, 12203 Berlin, Germany.
Krug SM; Clinical Physiology, Nutritional Medicine, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, 12203 Berlin, Germany.
Weiner J; Core Unit Bioinformatics (CUBI), Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Beule D; Core Unit Bioinformatics (CUBI), Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Gerhard R; Institute of Toxicology, Hannover Medical School, 30625 Hannover, Germany.
Schulzke JD; Clinical Physiology, Nutritional Medicine, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, 12203 Berlin, Germany.
Bücker R; Clinical Physiology, Nutritional Medicine, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, 12203 Berlin, Germany.

Toxins (Basel) ; 15(11)2023 11 04.

Article en En | MEDLINE | ID: mdl-37999506

Asunto(s)

Toxinas Bacterianas; Clostridioides difficile; Humanos; Proteínas de Uniones Estrechas/metabolismo; Toxinas Bacterianas/toxicidad; Toxinas Bacterianas/metabolismo; Clostridioides difficile/metabolismo; Uniones Estrechas/metabolismo; Clostridioides; Colon; Diarrea; Inflamación/metabolismo; Organoides; Mucosa Intestinal

Palabras clave

RNA-seq pathway analysis; actin; channel-forming claudin-2; claudin; cytokines; intestinal epithelial human colonic organoid monolayer; leak flux diarrhea; leaky gut; super-resolution STED microscopy; tricellulin

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Toxinas Bacterianas / Clostridioides difficile Idioma: En Revista: Toxins (Basel) Año: 2023 Tipo del documento: Article

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