One node among many: sevoflurane-induced hypnosis and the challenge of an integrative network-level view of anaesthetic action.
Br J Anaesth
; 132(2): 220-223, 2024 Feb.
Article
en En
| MEDLINE
| ID: mdl-38000931
ABSTRACT
Building on their known ability to influence sleep and arousal, Li and colleagues show that modulating the activity of glutamatergic pedunculopontine tegmental neurones also alters sevoflurane-induced hypnosis. This finding adds support for the shared sleep-anaesthesia circuit hypothesis. However, the expanding recognition of many neuronal clusters capable of modulating anaesthetic hypnosis raises the question of how disparate and anatomically distant sites ultimately interact to coordinate global changes in the state of the brain. Understanding how these individual sites work in concert to disrupt cognition and behaviour is the next challenge for anaesthetic mechanisms research.
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Anestésicos por Inhalación
/
Hipnosis
Idioma:
En
Revista:
Br J Anaesth
Año:
2024
Tipo del documento:
Article