Amyloid ß-Oligomers Inhibit the Nuclear Ca<sup>2+</sup> Signals and the Neuroprotective Gene Expression Induced by Gabazine in Hippocampal Neurons.

Lobos, Pedro; Vega-Vásquez, Ignacio; Bruna, Barbara; Gleitze, Silvia; Toledo, Jorge; Härtel, Steffen; Hidalgo, Cecilia; Paula-Lima, Andrea

Amyloid ß-Oligomers Inhibit the Nuclear Ca²⁺ Signals and the Neuroprotective Gene Expression Induced by Gabazine in Hippocampal Neurons.

Lobos, Pedro; Vega-Vásquez, Ignacio; Bruna, Barbara; Gleitze, Silvia; Toledo, Jorge; Härtel, Steffen; Hidalgo, Cecilia; Paula-Lima, Andrea.

Afiliación

Lobos P; Biomedical Neuroscience Institute, Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile.
Vega-Vásquez I; Advanced Clinical Research Center, Clinical Hospital, Universidad de Chile, Santiago 8380456, Chile.
Bruna B; Biomedical Neuroscience Institute, Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile.
Gleitze S; Advanced Scientific Equipment Network (REDECA), Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile.
Toledo J; Advanced Clinical Research Center, Clinical Hospital, Universidad de Chile, Santiago 8380456, Chile.
Härtel S; Biomedical Neuroscience Institute, Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile.
Hidalgo C; Advanced Clinical Research Center, Clinical Hospital, Universidad de Chile, Santiago 8380456, Chile.
Paula-Lima A; Advanced Scientific Equipment Network (REDECA), Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile.

Antioxidants (Basel) ; 12(11)2023 Nov 06.

Article en En | MEDLINE | ID: mdl-38001825

Palabras clave

Alzheimer's disease; amyloid-beta oligomers; antioxidant enzyme expression; calcium-dependent signaling pathways; calcium-mediated gene expression; gabazine; hippocampal cultures; neuronal activity; synaptotoxicity

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