Metastatic Penile Squamous Cell Carcinoma Responsive to Enfortumab Vedotin.
Int J Mol Sci
; 24(22)2023 Nov 09.
Article
en En
| MEDLINE
| ID: mdl-38003302
ABSTRACT
Penile squamous cell carcinoma is a rare disease with very limited data to guide treatment decisions. In particular, there is minimal evidence for effective therapies in the metastatic setting. Here, we present a case of metastatic penile squamous cell carcinoma with response to the Nectin-4 inhibitor enfortumab-vedotin-ejfv (EV). EV was selected due to the evidence of the high expression of Nectin-4 in squamous cell carcinomas, including penile carcinoma. The patient had both radiographic and symptomatic improvement after two cycles of treatment, despite having been treated with multiple prior lines of traditional chemotherapy. This case provides support for the use of antibody-drug conjugates (ADC), including EV, in this disease with few other options in the advanced setting. Further studies examining Nectin-4 and ADCs in penile squamous cell carcinoma should be completed, as high-quality evidence is needed to guide treatment after initial progression for these patients.
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Base de datos:
MEDLINE
Asunto principal:
Neoplasias del Pene
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Neoplasias de la Vejiga Urinaria
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Carcinoma de Células Escamosas
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Inmunoconjugados
Idioma:
En
Revista:
Int J Mol Sci
Año:
2023
Tipo del documento:
Article