Novel bioactive 2-phenyl-4-aminopyrimidine derivatives as EGFR<sup>Del19/T790M/C797S</sup> inhibitors for the treatment of non-small cell lung cancer.

Xu, Shidi; Zhou, Zhihui; He, Jie; Guo, Jiaojiao; Huang, Xiaoling; An, Yufeng; Pan, Qingshan; Xu, Shan; Zhu, Wufu

Novel bioactive 2-phenyl-4-aminopyrimidine derivatives as EGFR^{Del19/T790M/C797S} inhibitors for the treatment of non-small cell lung cancer.

Xu, Shidi; Zhou, Zhihui; He, Jie; Guo, Jiaojiao; Huang, Xiaoling; An, Yufeng; Pan, Qingshan; Xu, Shan; Zhu, Wufu.

Afiliación

Xu S; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang, Jiangxi, China.
Zhou Z; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang, Jiangxi, China.
He J; School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang, Jiangxi, China.
Guo J; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang, Jiangxi, China.
Huang X; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang, Jiangxi, China.
An Y; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang, Jiangxi, China.
Pan Q; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang, Jiangxi, China.
Xu S; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang, Jiangxi, China.
Zhu W; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang, Jiangxi, China.

Arch Pharm (Weinheim) ; 357(2): e2300460, 2024 Feb.

Article en En | MEDLINE | ID: mdl-38009481

Asunto(s)

Carcinoma de Pulmón de Células no Pequeñas; Neoplasias Pulmonares; Pirimidinas; Humanos; Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico; Carcinoma de Pulmón de Células no Pequeñas/genética; Carcinoma de Pulmón de Células no Pequeñas/patología; Receptores ErbB/metabolismo; Neoplasias Pulmonares/tratamiento farmacológico; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/patología; Mutación; Inhibidores de Proteínas Quinasas/farmacología; Inhibidores de Proteínas Quinasas/química; Relación Estructura-Actividad; Resistencia a Antineoplásicos; Línea Celular Tumoral

Palabras clave

EGFR inhibitor; EGFRDel19/T790M/C797S; NSCLC; antitumor activity

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Pirimidinas / Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares Idioma: En Revista: Arch Pharm (Weinheim) Año: 2024 Tipo del documento: Article

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