Baicalin exerts neuroprotective actions by regulating the Nrf2-NLRP3 axis in toxin-induced models of Parkinson's disease.

Huang, Jiahua; Zhang, Xinyue; Yang, Xueping; Yv, Qingyun; Ye, Fanlong; Chen, Sheng; Cui, Ying; Gu, Linting; Zhu, Min; Li, Wenwei

Huang, Jiahua; Zhang, Xinyue; Yang, Xueping; Yv, Qingyun; Ye, Fanlong; Chen, Sheng; Cui, Ying; Gu, Linting; Zhu, Min; Li, Wenwei.

Afiliación

Huang J; Laboratory of Neuropathology and Neuropharmacology, Department of Neurology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201500, China; Institute of Neurology, Institutes of Integrative Medicine, Fudan University, Shanghai 201500, China.
Zhang X; Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200443, China.
Yang X; Institute of Integrative Medicine, Department of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
Yv Q; Laboratory of Neuropathology and Neuropharmacology, Department of Neurology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201500, China; Institute of Neurology, Institutes of Integrative Medicine, Fudan University, Shanghai 201500, China.
Ye F; Laboratory of Neuropathology and Neuropharmacology, Department of Neurology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201500, China; Institute of Neurology, Institutes of Integrative Medicine, Fudan University, Shanghai 201500, China.
Chen S; Laboratory of Neuropathology and Neuropharmacology, Department of Neurology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201500, China; Institute of Neurology, Institutes of Integrative Medicine, Fudan University, Shanghai 201500, China.
Cui Y; Laboratory of Neuropathology and Neuropharmacology, Department of Neurology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201500, China; Institute of Neurology, Institutes of Integrative Medicine, Fudan University, Shanghai 201500, China.
Gu L; Laboratory of Neuropathology and Neuropharmacology, Department of Neurology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201500, China; Institute of Neurology, Institutes of Integrative Medicine, Fudan University, Shanghai 201500, China.
Zhu M; Shanghai Key Laboratory of Visual Impairment and Restoration, Eye & ENT Hospital, Fudan University, Shanghai 200031, China. Electronic address: min.zhu@fdeent.org.cn.
Li W; Laboratory of Neuropathology and Neuropharmacology, Department of Neurology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201500, China; Institute of Neurology, Institutes of Integrative Medicine, Fudan University, Shanghai 201500, China. Electronic address: wenweili2000@aliyun

Chem Biol Interact ; 387: 110820, 2024 Jan 05.

Article en En | MEDLINE | ID: mdl-38016618

Asunto(s)

Flavonoides; Intoxicación por MPTP; Fármacos Neuroprotectores; Enfermedad de Parkinson; Animales; Ratones; Antioxidantes/metabolismo; Modelos Animales de Enfermedad; Neuronas Dopaminérgicas; Flavonoides/farmacología; Flavonoides/uso terapéutico; Flavonoides/metabolismo; Inflamasomas/metabolismo; Ratones Endogámicos C57BL; Microglía; Intoxicación por MPTP/metabolismo; Fármacos Neuroprotectores/farmacología; Fármacos Neuroprotectores/uso terapéutico; Fármacos Neuroprotectores/metabolismo; Factor 2 Relacionado con NF-E2/metabolismo; Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo; Enfermedad de Parkinson/tratamiento farmacológico; Enfermedad de Parkinson/metabolismo

Palabras clave

Baicalin; Inflammation; NLRP3 inflammasome; Oxidative stress; Parkinson's disease

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Flavonoides / Fármacos Neuroprotectores / Intoxicación por MPTP Idioma: En Revista: Chem Biol Interact Año: 2024 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google