Associations of Folate/Folic Acid Supplementation Alone and in Combination With Other B Vitamins on Dementia Risk and Brain Structure: Evidence From 466 224 UK Biobank Participants.
J Gerontol A Biol Sci Med Sci
; 79(4)2024 Apr 01.
Article
en En
| MEDLINE
| ID: mdl-38029284
ABSTRACT
Previous researchers have tried to explore the association between folate/folic acid intake and dementia incidence, but the results remain controversial. We evaluated the associations of folate/folic acid supplementation alone and in combination with other B vitamins on dementia risk and brain structure. A total of 466â
224 UK Biobank participants were investigated. Cox proportional hazards models were used to assess the associations between folate/folic acid supplementation status and the risk of Alzheimer's disease (AD) and vascular dementia (VD). Multivariable linear regression models were employed to evaluate the association between folate/folic acid supplementation status and brain structure. In the final model, folate/folic acid supplementation alone was significantly associated with a higher risk of AD (hazard ratio [HR]â
=â
1.34, 95% confidence interval [CI]â
=â
1.06-1.69, pâ
=â
.015) and VD (HRâ
=â
1.61, 95% CIâ
=â
1.21-2.13, pâ
=â
.001). Folate/folic acid supplementation alone was associated with a reduction in the hippocampus (ßâ
=â
-95.25 mm3, 95% CIâ
=â
-165.31 to -25.19 mm3, pâ
=â
.014) and amygdala (ßâ
=â
-51.85 mm3, 95% CIâ
=â
-88.02 to -15.68 mm3, pâ
=â
.012). The risk of AD and VD, as well as brain structure, in the group with combined folate/folic acid supplementation and other B vitamins did not show a statistically significant difference compared to the reference group (all pâ
>â
.05). Folate/folic acid supplementation alone is significantly associated with a higher risk of AD and VD, as well as adverse alterations in brain structure. However, when combined with other B vitamins, these detrimental effects can be counteracted.
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Base de datos:
MEDLINE
Asunto principal:
Complejo Vitamínico B
/
Demencia
Idioma:
En
Revista:
J Gerontol A Biol Sci Med Sci
Asunto de la revista:
GERIATRIA
Año:
2024
Tipo del documento:
Article