Anaplasmosis encephalitis and infection of non-myeloid bone marrow precursors.
BMJ Case Rep
; 16(11)2023 Nov 30.
Article
en En
| MEDLINE
| ID: mdl-38035680
ABSTRACT
Due to climate change, infections from tickborne pathogens are becoming more prevalent in the Northern Hemisphere. Human granulocytic anaplasmosis, caused by the obligate intracellular gram-negative bacteria Anaplasma phagocytophilum and carried by Ixodes ticks, can lead to morbidity and mortality in select populations. Anaplasmosis is commonly accompanied by significant cytopaenia, the pathophysiology of which remains unknown. Our case report describes an uncommon meningoencephalitic presentation of anaplasmosis with substantial anaemia and thrombocytopaenia. Additionally, we propose a mechanism of bone marrow infection and suppression by A. phagocytophilum which may be responsible for the cytopaenia in anaplasmosis and provide pictographic evidence of anaplasma in peripheral blood, cerebrospinal fluid and bone marrow.
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Ixodes
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Anaplasma phagocytophilum
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Encefalitis
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Anaplasmosis
Idioma:
En
Revista:
BMJ Case Rep
Año:
2023
Tipo del documento:
Article