Knockout of IRF3 and IRF7 genes by CRISPR/Cas9 technology enhances porcine virus replication in the swine testicular (ST) cell line.

Sun, Xiamei; Wang, Jing; Mou, Chunxiao; Shi, Kaichuang; Bao, Wenbin; Chen, Zhenhai

Sun, Xiamei; Wang, Jing; Mou, Chunxiao; Shi, Kaichuang; Bao, Wenbin; Chen, Zhenhai.

Afiliación

Sun X; College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China.
Wang J; College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China.
Mou C; College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China.
Shi K; Guangxi Center for Animal Disease Control and Prevention, Nanning, Guangxi, China.
Bao W; Key Laboratory for Animal Genetics, Breeding, Reproduction and Molecular Design of Jiangsu, Yangzhou, Jiangsu, China.
Chen Z; College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China.

Biotechnol J ; 19(1): e2300389, 2024 Jan.

Article en En | MEDLINE | ID: mdl-38047496

Asunto(s)

Sistemas CRISPR-Cas; Replicación Viral; Animales; Porcinos; Sistemas CRISPR-Cas/genética; Línea Celular; Replicación Viral/genética; Edición Génica; Antivirales/farmacología

Palabras clave

CRISPER/Cas9; IRF3; IRF7; interferon; virus titer

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Replicación Viral / Sistemas CRISPR-Cas Idioma: En Revista: Biotechnol J Asunto de la revista: BIOTECNOLOGIA Año: 2024 Tipo del documento: Article

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