A Comprehensive Review of Modifiable Cardiovascular Risk Factors and Genetic Influences in Dementia Prevention.

Dementia poses a growing global health challenge, demanding a multifaceted approach to prevention. This comprehensive review delves into the interplay between modifiable cardiovascular risk factors and genetic influences in dementia prevention. We examine key risk factors, including hypertension, diabetes, hyperlipidemia, obesity, smoking, and physical inactivity, elucidating their impact on dementia risk and the underlying biological mechanisms. Genetic factors, notably familial Alzheimer's disease (FAD) and the apolipoprotein E (APOE) gene, are explored in detail, offering insights into their contributions to dementia susceptibility. Importantly, we highlight the complex interrelationship between genetics and modifiable risk factors, emphasizing the need for personalized prevention strategies. Integrating lifestyle modifications and genetic considerations, a holistic approach is paramount in dementia prevention. Implications for public health initiatives and clinical practices underscore the urgency of tailored interventions. Our call to action urges continued research, precision medicine implementation, and collaborative efforts to mitigate the burden of dementia and enhance cognitive well-being globally.