Elemental Sulfur-Mediated Aromatic Halogenation.
J Org Chem
; 89(1): 770-777, 2024 Jan 05.
Article
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| MEDLINE
| ID: mdl-38113515
ABSTRACT
A method for aromatic halogenation using a combination of elemental sulfur (S8) and N-halosuccinimide has been developed. A catalytic quantity of elemental sulfur (S8) with N-bromosuccinimide (NBS) and N-chlorosuccinimide (NCS) effectively halogenated less-reactive aromatic compounds, such as ester-, cyano-, and nitro-substituted anisole derivatives. No reaction occurred in the absence of S8, underscoring its crucial role in the catalytic activity. This catalytic system was also applicable to aromatic iodination with 1,3-diiodo-5,5-dimethylhydantoin.
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MEDLINE
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En
Revista:
J Org Chem
Año:
2024
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Article