Dequalinium Chloride for the Treatment of Vulvovaginal Infections: A Systematic Review and Meta-Analysis.
J Low Genit Tract Dis
; 28(1): 76-83, 2024 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-38117564
ABSTRACT
OBJECTIVE/PURPOSE:
Women at reproductive age frequently experience vulvovaginal infections and vaginitis. The most common etiologies are vulvovaginal candidiasis (VVC), bacterial vaginosis (BV), desquamative inflammatory vaginitis/aerobic vaginitis, and trichomoniasis. Various treatment options are available for these infections, such as specific antimicrobial or antiseptic agents. Dequalinium chloride (DQC) is a local antiseptic agent with a broad antimicrobial and antifungal spectrum. Multiple studies suggest that DQC is an efficient treatment for vaginal infections; however, it is not widely recommended as a first-line treatment. This systematic review and meta-analysis aims to evaluate the efficacy of DQC compared with that of standard treatment.METHODS:
Our systematic review was conducted according to the PRISMA guidelines. PubMed/MEDLINE, EMBASE, CENTRAL, and clinicaltrials.org were searched to retrieve relevant reports up to October 2022.RESULTS:
Four randomized controlled studies and 1 observational study were included in this review. Overall, DQC showed noninferiority to the reference treatments for BV and VVC, and to the evaluated treatment options for desquamative inflammatory vaginitis/aerobic vaginitis. For BV and VVC, this could also be confirmed in a meta-analysis including 3 randomized controlled studies. No serious adverse events were reported in any of these studies.CONCLUSIONS:
Dequalinium chloride offers a safe, well-tolerated, and efficient treatment option for vulvovaginal infections of different etiologies. However, further studies are needed to confirm our findings and allow inclusion of DQC as a first-line treatment into guidelines.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Vulvovaginitis
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Candidiasis Vulvovaginal
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Vaginosis Bacteriana
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Decualinio
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Antiinfecciosos
/
Antiinfecciosos Locales
Tipo de estudio:
Systematic_reviews
Idioma:
En
Revista:
J Low Genit Tract Dis
/
J. low. genit. tract dis
/
Journal of lower genital tract disease
Asunto de la revista:
GINECOLOGIA
Año:
2024
Tipo del documento:
Article