PD-L1 inhibitor plus gemcitabine and cisplatin therapy followed by conversion surgery for initially unresectable advanced gallbladder cancer.
BMJ Case Rep
; 16(12)2023 Dec 20.
Article
en En
| MEDLINE
| ID: mdl-38123314
ABSTRACT
Advanced gallbladder cancer (GBC) is not amenable to surgical resection. There are limited treatment options and the prognosis is dismal. The role of immune checkpoint inhibitors in conversion therapy remains unclear for initially unresectable advanced GBC. We present a case of a woman in her late 60s diagnosed with stage IV GBC with liver and para-aortic and retroperitoneal lymph node metastases, who achieved a pathological complete response after three cycles of programmed cell death-ligand 1 inhibitor durvalumab combined with gemcitabine and cisplatin regimen and underwent conversion surgery without complication. The patient went on to develop disease progression without adjuvant therapy 6 months after surgery.
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Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Vesícula Biliar
/
Gemcitabina
Idioma:
En
Revista:
BMJ Case Rep
/
BMJ case reports
Año:
2023
Tipo del documento:
Article