Synthesis and application of bacterial exopolysaccharides.
Curr Opin Chem Biol
; 78: 102418, 2024 02.
Article
en En
| MEDLINE
| ID: mdl-38134611
ABSTRACT
Exopolysaccharides are produced and excreted by bacteria in the generation of biofilms to provide a protective environment. These polysaccharides are generally generated as heterogeneous polymers of varying length, featuring diverse substitution patterns. To obtain well-defined fragments of these polysaccharides, organic synthesis often is the method of choice, as it allows for full control over chain length and the installation of a pre-determined substitution pattern. This review presents several recent syntheses of exopolysaccharide fragments of Pseudomonas aeruginosa and Staphylococcus aureus and illustrates how these have been used to study biosynthesis enzymes and generate synthetic glycoconjugate vaccines.
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Polisacáridos Bacterianos
/
Biopelículas
Idioma:
En
Revista:
Curr Opin Chem Biol
/
Curr. opin. chem. biol
/
Current opinion in chemical biology
Asunto de la revista:
BIOQUIMICA
Año:
2024
Tipo del documento:
Article