Isolated polyhydramnios: Is a genetic evaluation of value?
Eur J Obstet Gynecol Reprod Biol
; 293: 115-118, 2024 Feb.
Article
en En
| MEDLINE
| ID: mdl-38141485
ABSTRACT
OBJECTIVE:
To analyze the risk for genetic aberrations and pregnancy outcomes in pregnancies with isolated polyhydramnios. STUDYDESIGN:
This was a retrospective study of singleton pregnancies complicated by isolated polyhydramnios that underwent genetic amniocentesis between 2016 and 2021. Clinical and laboratory data were collected and reviewed for these cases, including maternal demographics, prenatal sonographic findings, chromosomal microarray results, and pregnancy outcomes.RESULTS:
A total of 94 singleton pregnancies were included. Three (3.2%) cases with chromosomal abnormalities were detected, including 2 case of trisomy 21 and 1 of 22q21.1 microdeletion. One case was diagnosed as Prader-Willi syndrome caused by maternal uniparental disomy of chromosome 15. Perinatal death occurred in 1 case with severe polyhydramnios, and was retrospectively diagnosed as Bartter syndrome. Of the 90 infants survived, two were identified to have single gene disorders after birth by whole exome sequencing.CONCLUSION:
We first attempted to determine the value of exome sequencing in pregnancies with isolated polyhydramnios. Our results warrant more studies to evaluate advanced genetic testing technologies used in such pregnancies.Palabras clave
Texto completo:
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Base de datos:
MEDLINE
Asunto principal:
Polihidramnios
Idioma:
En
Revista:
Eur J Obstet Gynecol Reprod Biol
Año:
2024
Tipo del documento:
Article