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SMAD7 gene polymorphisms and their influence on patients with colorectal cancer.
Wu, Yongsheng; Xu, Jue; Tan, Biaobin; Yi, Ting; Liu, Su; Yang, Guang; Li, Kai; Zhao, Xinhan.
Afiliación
  • Wu Y; Department of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Xu J; The Second Ward of Oncology and Hematology Department, The People's Hospital of XiangXiang, Xiangxiang, China.
  • Tan B; Department of Intrarenal Rheumatology and Immunology, The People's Hospital of XiangXiang, Xiangxiang, China.
  • Yi T; The Second Ward of Oncology and Hematology Department, The People's Hospital of XiangXiang, Xiangxiang, China.
  • Liu S; The Second Ward of Oncology and Hematology Department, The People's Hospital of XiangXiang, Xiangxiang, China.
  • Yang G; The Second Ward of Oncology and Hematology Department, The People's Hospital of XiangXiang, Xiangxiang, China.
  • Li K; The Second Ward of Oncology and Hematology Department, The People's Hospital of XiangXiang, Xiangxiang, China.
  • Zhao X; The Second Ward of Oncology and Hematology Department, The People's Hospital of XiangXiang, Xiangxiang, China.
Cell Cycle ; 22(21-22): 2424-2435, 2023 11.
Article en En | MEDLINE | ID: mdl-38146644
ABSTRACT
Colorectal cancer (CRC) is a prevalent malignant tumor, and its pathogenesis is still not fully understood. Studies have shown that SMAD7 gene polymorphisms can affect CRC susceptibility, but the results have been inconsistent and require additional confirmation. Our study aimed to evaluate the effect of SMAD7 variants on the risk of CRC in the Chinese Han population. A total of five single nucleotide polymorphisms (SNPs) in SMAD7 were genotyped among 696 CRC patients and 696 healthy participants using the MassARRAY iPLEX platform. SNPs were evaluated for their associations with CRC using logistic regression analysis under multiple genetic models. The false-positive report probability (FPRP) analysis was used to validate the positive findings. Our study indicated that rs11874392 showed an increased association with CRC risk (odds ratio, 1.31; 95% confidence interval, 1.04-1.67; p = 0.024). Stratified analysis showed that rs11874392 might increase the risk of CRC in females (OR = 1.70, p = 0.028), individuals with smoking (OR = 1.87, p = 0.026), and drinking (OR = 1.38, p = 0.027). The rs11874392 was found to be related to an elevated risk of rectal cancer (OR = 1.73, p = 0.003), but not with colon cancer. FPRP analysis demonstrated that all of these associations were statistically significant (FPRP <0.2). Additionally, rs11874392 was the strongest predictive model for CRC. This study provides evidence that the SMAD7 rs11874392 is related to an increased susceptibility to CRC.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Predisposición Genética a la Enfermedad Idioma: En Revista: Cell Cycle Año: 2023 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Predisposición Genética a la Enfermedad Idioma: En Revista: Cell Cycle Año: 2023 Tipo del documento: Article