Natural products in traditional Chinese medicine: molecular mechanisms and therapeutic targets of renal fibrosis and state-of-the-art drug delivery systems.
Biomed Pharmacother
; 170: 116039, 2024 Jan.
Article
en En
| MEDLINE
| ID: mdl-38157643
ABSTRACT
Renal fibrosis (RF) is the end stage of several chronic kidney diseases. Its series of changes include excessive accumulation of extracellular matrix, epithelial-mesenchymal transition (EMT) of renal tubular cells, fibroblast activation, immune cell infiltration, and renal cell apoptosis. RF can eventually lead to renal dysfunction or even renal failure. A large body of evidence suggests that natural products in traditional Chinese medicine (TCM) have great potential for treating RF. In this article, we first describe the recent advances in RF treatment by several natural products and clarify their mechanisms of action. They can ameliorate the RF disease phenotype, which includes apoptosis, endoplasmic reticulum stress, and EMT, by affecting relevant signaling pathways and molecular targets, thereby delaying or reversing fibrosis. We also present the roles of nanodrug delivery systems, which have been explored to address the drawback of low oral bioavailability of natural products. This may provide new ideas for using natural products for RF treatment. Finally, we provide new insights into the clinical prospects of herbal natural products.
Palabras clave
Apigenin (Pubmed CID: 5280443); Astragaloside IV (Pubmed CID: 13943297); Berberine (Pubmed CID: 2353); Calycosin (Pubmed CID: 5280448)ï¼Dihydromyricetin (Pubmed CID: 161557); Chrysophanol (Pubmed CID: 10208); Curcumin (Pubmed CID: 969516); Dihydroquercetin (Pubmed CID: 439533); Emodin (Pubmed CID: 3220); Epigallocatechin-3-Gallate (Pubmed CID: 65064); Flavonoids; Ginsenoside Rg1 (Pubmed CID: 441923); Isoliquiritigenin (Pubmed CID: 638278); NDSS; Natural products; Oxymatrine (Pubmed CID: 114850); Pectolinarigenin (Pubmed CID: 5320438); Phenols; Puerarin (Pubmed CID: 5281807); Quercetin (Pubmed CID: 5280343); Renal fibrosis; Resveratrol (Pubmed CID: 445154); Rhein (Pubmed CID: 10168); Salidroside (Pubmed CID: 159278); Salvianolic acid B (Pubmed CID: 6541084); Tanshinone IIA (Pubmed CID: 164676)
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Productos Biológicos
/
Medicamentos Herbarios Chinos
/
Enfermedades Renales
Idioma:
En
Revista:
Biomed Pharmacother
Año:
2024
Tipo del documento:
Article