Human trials exploring anti-aging medicines.
Cell Metab
; 36(2): 354-376, 2024 02 06.
Article
en En
| MEDLINE
| ID: mdl-38181790
ABSTRACT
Here, we summarize the current knowledge on eight promising drugs and natural compounds that have been tested in the clinic metformin, NAD+ precursors, glucagon-like peptide-1 receptor agonists, TORC1 inhibitors, spermidine, senolytics, probiotics, and anti-inflammatories. Multiple clinical trials have commenced to evaluate the efficacy of such agents against age-associated diseases including diabetes, cardiovascular disease, cancer, and neurodegenerative diseases. There are reasonable expectations that drugs able to decelerate or reverse aging processes will also exert broad disease-preventing or -attenuating effects. Hence, the outcome of past, ongoing, and future disease-specific trials may pave the way to the development of new anti-aging medicines. Drugs approved for specific disease indications may subsequently be repurposed for the treatment of organism-wide aging consequences.
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Base de datos:
MEDLINE
Asunto principal:
Enfermedades Cardiovasculares
/
Metformina
/
Neoplasias
Idioma:
En
Revista:
Cell Metab
Asunto de la revista:
METABOLISMO
Año:
2024
Tipo del documento:
Article