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Numerical investigation of a graphene-on-semiconductor device for optical monitoring of cell electrophysiology.
Gorecki, Jon; Krause, Steffi.
Afiliación
  • Gorecki J; Department of Bioengineering, Imperial College London, Exhibition Road, London SW7 2BX, UK.
  • Krause S; School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, UK.
iScience ; 27(1): 108554, 2024 Jan 19.
Article en En | MEDLINE | ID: mdl-38188511
ABSTRACT
Spatially resolved sensing devices for electrostatic potentials are extremely useful for characterization of living cells, however, many current techniques lack the speed necessary to capture spatially resolved, functional information of cells in real-time. Here, an optical sensing technique is proposed based on graphene on a semiconductor stack operating in the near-infrared spectrum. By modeling coherent interference of multiply reflected beam paths within the semiconductor stack, we demonstrate how the device produces a continuous reflectivity change in response to graphene Fermi energy which is ideal for sensing changes in local electrostatic fields produced by action potentials of living cells. By coupling the device with a high-speed camera, we propose this platform will allow for high-speed imaging of action potentials over a large sensing area with micron scale resolution.
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Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: IScience Año: 2024 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: IScience Año: 2024 Tipo del documento: Article