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A reductively convertible nickel phthalocyanine precursor as a biological thiol-responsive turn-on photoacoustic contrast agent.
Nogita, Kohei; Sugahara, Takaya; Miki, Koji; Mu, Huiying; Kobayashi, Minoru; Harada, Hiroshi; Ohe, Kouichi.
Afiliación
  • Nogita K; Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan. kojimiki@scl.kyoto-u.ac.jp.
  • Sugahara T; Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan. kojimiki@scl.kyoto-u.ac.jp.
  • Miki K; Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan. kojimiki@scl.kyoto-u.ac.jp.
  • Mu H; Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan. kojimiki@scl.kyoto-u.ac.jp.
  • Kobayashi M; Laboratory of Cancer Cell Biology, Graduate School of Biostudies, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
  • Harada H; Laboratory of Cancer Cell Biology, Graduate School of Biostudies, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
  • Ohe K; Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan. kojimiki@scl.kyoto-u.ac.jp.
Chem Commun (Camb) ; 60(11): 1472-1475, 2024 Feb 01.
Article en En | MEDLINE | ID: mdl-38224167
ABSTRACT
A nickel phthalocyanine precursor bearing poly(ethylene glycol) as a turn-on contrast agent for photoacoustic imaging was prepared. The water-soluble polymeric chains were smoothly eliminated through thiol-mediated reductive aromatization in cancer cells, enabling the detection of endogenous biological thiols in vitro and in vivo.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Medios de Contraste / Isoindoles / Técnicas Fotoacústicas Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article
Texto completo
Imprimir
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Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Medios de Contraste / Isoindoles / Técnicas Fotoacústicas Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article