Glucagon-like peptide-1 and interleukin-6 interaction in response to physical exercise: An in-silico model in the framework of immunometabolism.
Comput Methods Programs Biomed
; 245: 108018, 2024 Mar.
Article
en En
| MEDLINE
| ID: mdl-38262127
ABSTRACT
BACKGROUND AND OBJECTIVE:
Glucagon-like peptide 1 (GLP-1) is classically identified as an incretin hormone, secreted in response to nutrient ingestion and able to enhance glucose-stimulated insulin secretion. However, other stimuli, such as physical exercise, may enhance GLP-1 plasma levels, and this exercise-induced GLP-1 secretion is mediated by interleukin-6 (IL-6), a cytokine secreted by contracting skeletal muscle. The aim of the study is to propose a mathematical model of IL-6-induced GLP-1 secretion and kinetics in response to physical exercise of moderate intensity.METHODS:
The model includes the GLP-1 subsystem (with two pools gut and plasma) and the IL-6 subsystem (again with two pools skeletal muscle and plasma); it provides a parameter of possible clinical relevance representing the sensitivity of GLP-1 to IL-6 (k0). The model was validated on mean IL-6 and GLP-1 data derived from the scientific literature and on a total of 100 virtual subjects.RESULTS:
Model validation provided mean residuals between 0.0051 and 0.5493 pgâ mL-1 for IL-6 (in view of concentration values ranging from 0.8405 to 3.9718 pgâ mL-1) and between 0.0133 and 4.1540 pmolâ L-1 for GLP-1 (in view of concentration values ranging from 0.9387 to 17.9714 pmolâ L-1); a positive significant linear correlation (r = 0.85, p<0.001) was found between k0 and the ratio between areas under GLP-1 and IL-6 curve, over the virtual subjects.CONCLUSIONS:
The model accurately captures IL-6-induced GLP-1 kinetics in response to physical exercise.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Interleucina-6
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Péptido 1 Similar al Glucagón
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Comput Methods Programs Biomed
Asunto de la revista:
INFORMATICA MEDICA
Año:
2024
Tipo del documento:
Article