Risk and effect modifiers for poor glycemic control among the chinese diabetic adults on statin therapy: the kailuan study.
Clin Res Cardiol
; 113(8): 1219-1231, 2024 Aug.
Article
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| MEDLINE
| ID: mdl-38265512
ABSTRACT
BACKGROUND:
Limited studies have investigated the association between statin therapy and poor glycemic control, especially in the Chinese diabetic population.METHODS:
Two prospective diabetes cohorts were drawn from the Kailuan Cohort. In Cohort 1, linear regression models were used to evaluate the association between statin therapy and glycated hemoglobin (HbA1c) level change. In Cohort 2, new user design and conditional logistic models were used to assess associations between statin initiation and poor glycemic control which was a composite outcome comprised of hypoglycemic agent escalation and new-onset hyperglycemia.RESULTS:
Among 11,755 diabetic patients with medication information, 1400 statin users and 1767 statin nonusers with repeated HbA1c measurements were included in Cohort 1 (mean age 64.6 ± 10.0 years). After a median follow-up of 3.02 (1.44, 5.00) years, statin therapy was associated with higher HbA1c levels (ß 0.20%; 95%CI 0.05% to 0.34%). In Cohort 2, 1319 pairs of matched cases/controls were included (mean age 61.6 ± 9.75 years). After a median follow-up of 4.87 (2.51, 8.42) years, poor glycemic control occurred in 43.0% of statin new users and 31.8% of statin nonusers (OR 1.69; 95% CI 1.32 to 2.17; P < 0.001). The statin-associated poor glycemic control risk was significantly higher among patients with lower body mass index (Pint = 0.089). Furthermore, a nonlinear association was observed between statin therapy duration and poor glycemic control (P = 0.003).CONCLUSIONS:
Among Chinese diabetic adults, statin therapy was associated with a higher level of HbA1c, and a higher risk of hypoglycemic agent escalation and new-onset hyperglycemia, especially among those who had lower body mass index levels and longer statin therapy duration.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Glucemia
/
Hemoglobina Glucada
/
Inhibidores de Hidroximetilglutaril-CoA Reductasas
/
Control Glucémico
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
País/Región como asunto:
Asia
Idioma:
En
Revista:
Clin Res Cardiol
Asunto de la revista:
CARDIOLOGIA
Año:
2024
Tipo del documento:
Article