Association study of a single nucleotide polymorphism in the hypoxia response element of the macrophage migration inhibitory factor gene promoter with suicide completers in the Japanese population.
Neuropsychopharmacol Rep
; 44(1): 262-266, 2024 Mar.
Article
en En
| MEDLINE
| ID: mdl-38267013
ABSTRACT
BACKGROUND:
More than 800 000 people die by suicide annually. The heritability of suicide is 30%-50%. We focused on the hypoxia response element (HRE), which promotes the expression of macrophage migration inhibitory factor (MIF) via the hypoxia-inducible factor (HIF) pathway, important in neurogenesis and neuroprotection. We examined a genetic polymorphism of rs17004038, a single-nucleotide polymorphism (SNP), in suicide completers and controls.METHODS:
The study population included 1336 suicide completers and 814 unrelated healthy controls. All participants were Japanese. We obtained peripheral blood, extracted DNA, and genotyped the patients for SNP rs17004038 (C > A).RESULTS:
No significant differences were observed between the two groups in either the allele or genotype analyses. Subgroup analyses by sex, age (<40 or ≥40), and suicide method (violent or nonviolent suicide) were performed with similar results.CONCLUSION:
No association was observed between SNP rs17004038 and suicide completion. Although it is challenging to collect a large number of samples from suicide completers, further MIF-related genetic studies, including those of rs17004038, are necessary with larger sample sizes.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Suicidio
/
Factores Inhibidores de la Migración de Macrófagos
Tipo de estudio:
Risk_factors_studies
País/Región como asunto:
Asia
Idioma:
En
Revista:
Neuropsychopharmacol Rep
Año:
2024
Tipo del documento:
Article