A genomics perspective of personalized prevention and management of obesity.
Hum Genomics
; 18(1): 4, 2024 Jan 29.
Article
en En
| MEDLINE
| ID: mdl-38281958
ABSTRACT
This review discusses the landscape of personalized prevention and management of obesity from a nutrigenetics perspective. Focusing on macronutrient tailoring, we discuss the impact of genetic variation on responses to carbohydrate, lipid, protein, and fiber consumption. Our bioinformatic analysis of genomic variants guiding macronutrient intake revealed enrichment of pathways associated with circadian rhythm, melatonin metabolism, cholesterol and lipoprotein remodeling and PPAR signaling as potential targets of macronutrients for the management of obesity in relevant genetic backgrounds. Notably, our data-based in silico predictions suggest the potential of repurposing the SYK inhibitor fostamatinib for obesity treatment in relevant genetic profiles. In addition to dietary considerations, we address genetic variations guiding lifestyle changes in weight management, including exercise and chrononutrition. Finally, we emphasize the need for a refined understanding and expanded research into the complex genetic landscape underlying obesity and its management.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Dieta
/
Obesidad
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Hum Genomics
Asunto de la revista:
GENETICA
Año:
2024
Tipo del documento:
Article