Mercaptopyrimidine-templated gold nanoclusters for antithrombotic therapy.
J Mater Chem B
; 12(7): 1775-1781, 2024 Feb 14.
Article
en En
| MEDLINE
| ID: mdl-38284142
ABSTRACT
Here we report for the first time that mercaptopyrimidine-templated gold nanoclusters (DAMP-AuNCs) can be used as a novel anticoagulant candidate for the design of antithrombotic drugs. Anticoagulant mechanisms revealed that DAMP-AuNCs significantly inhibited thrombus formation by interacting with fibrinogen. Carrageenan-induced mice tail thrombosis model experiments showed that DAMP-AuNCs had antithrombotic efficacy comparable to heparin in vivo. More importantly, these ultrasmall AuNCs possess excellent blood compatibility and only induce negligible bleeding side effects. Our study is a successful attempt at developing novel antithrombotic agents with high biosafety.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Fibrinolíticos
/
Oro
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
J Mater Chem B
Año:
2024
Tipo del documento:
Article