[Primary testicular NK/T cell lymphoma. Case report and review of literature]. / Linfoma de células T/NK primario de testículo. Caso clínico y revisión de la literatura.
Rev Med Chil
; 151(3): 381-386, 2023 Mar.
Article
en Es
| MEDLINE
| ID: mdl-38293884
ABSTRACT
Natural killer/T cell lymphomas chiefly involving the midline facial structures including the nasal cavity or nasopharyns are a relatively rare type of non-Hodgkin's lymphoma. Apart from the upper respiratory tract, the disease occasionally presents in certain extranodal sites, such as the central nervous system, skin, gastrointestinal tract, or testes. We report a case of natural killer NK/T cell lymphoma as a testicular tumor in a 36-year-old man with a history of progressive swelling of his right testicle. Histologically, the testicular mass showed a diffuse infiltrate of medium-sized and atypical large lymphoid cells with angiocentric infiltration and areas of coagulative necrosis. Immunohistochemical studies demonstrated tumor cells staining positively with CD3, TIA-1, and Granzyme B. The Epstein-Barr virus genoma was detected by in situ hybridization. There were no abnormal findings in the nasal and nasopharyngeal regions. Classified as stage IEA, the patient received involved-field irradiation to contralateral testis (45 Gy), followed by systemic chemotherapy with a combination regimen ofL-asparaginase, methotrexate and dexamethasone. Relevant literature is reviewed, and the clinicopathologic features, natural history, and treatment options for primary testicular NK/T cell lymphoma are discussed.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Linfoma de Células T
/
Infecciones por Virus de Epstein-Barr
Idioma:
Es
Revista:
Rev Med Chil
Año:
2023
Tipo del documento:
Article