18 F-FDG PET/CT characteristics of IASLC grade 3 invasive adenocarcinoma and the value of 18 F-FDG PET/CT for preoperative prediction: a new prognostication model.
Nucl Med Commun
; 45(4): 338-346, 2024 Apr 01.
Article
en En
| MEDLINE
| ID: mdl-38312089
ABSTRACT
OBJECTIVE:
This study is performed to investigate the imaging characteristics of the International Association for the Study of Lung Cancer grade 3 invasive adenocarcinoma (IAC) on PET/CT and the value of PET/CT for preoperative predicting this tumor. MATERIALS ANDMETHODS:
We retrospectively enrolled patients with IAC from August 2015 to September 2022. The clinical characteristics, serum tumor markers, and PET/CT features were analyzed. T test, Mann-Whitney U test, χ 2 test, Logistic regression analysis, and receiver operating characteristic analysis were used to predict grade 3 tumor and evaluate the prediction effectiveness.RESULTS:
Grade 3 tumors had a significantly higher maximum standardized uptake value (SUV max ) and consolidation-tumor-ratio (CTR) ( P â <â 0.001), while Grade 1 - 2 tumors were prone to present with air bronchogram sign or vacuole sign ( P â <â 0.001). A stepwise logistic regression analysis revealed that smoking history, CEA, SUV max , air bronchogram sign or vacuole sign and CTR were useful predictors for Grade 3 tumors. The established prediction model based on the above 5 parameters generated a high AUC (0.869) and negative predictive value (0.919), respectively.CONCLUSION:
Our study demonstrates that grade 3 IAC has a unique PET/CT imaging feature. The prognostication model established with smoking history, CEA, SUV max , air bronchogram sign or vacuole sign and CTR can effectively predict grade 3 tumors before the operation.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Adenocarcinoma
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Adenocarcinoma del Pulmón
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Neoplasias Pulmonares
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Nucl Med Commun
/
Nucl. med. commun
/
Nuclear medicine communications
Año:
2024
Tipo del documento:
Article