Hypothalamic-pituitary-adrenal axis recovery after intermediate-acting glucocorticoid treatment in client-owned dogs.
J Vet Intern Med
; 38(2): 942-950, 2024.
Article
en En
| MEDLINE
| ID: mdl-38321784
ABSTRACT
BACKGROUND:
In dogs, duration of hypothalamic-pituitary-adrenal (HPA) axis suppression after systemic glucocorticoid treatment is reported to vary from a few days to up to 7 weeks after glucocorticoid discontinuation. These data are derived mainly from experimental studies in healthy dogs and not from animals with spontaneous disease. HYPOTHESIS ANDOBJECTIVE:
To determine the timeline for recovery of the HPA axis in a group of ill dogs treated with intermediate-acting glucocorticoids (IAGCs). ANIMALS Twenty client-owned dogs that received IAGC for at least 1 week.METHODS:
Single-center prospective observational study. An ACTH stimulation test, endogenous ACTH concentration, serum biochemistry profile, and urinalysis were performed at T0 (2-6 days after IAGC discontinuation) and then every 2 weeks (eg, T1, T2, T3) until HPA axis recovery was documented (post-ACTH cortisol concentration > 6 µg/dL).RESULTS:
The median time of HPA axis recovery was 3 days (range, 2-133 days). Eleven of 20 dogs showed recovery of the HPA axis at T0, 6/20 at T1, and 1 dog each at T2, T5, and T9. Dose and duration of treatment were not correlated with timing of HPA axis recovery. Activities of ALT and ALP were significantly correlated with the post-ACTH cortisol concentration (rs = -0.34, P = .03; rs = -0.31, P = .05). Endogenous ACTH concentration was significantly correlated with pre (r = 0.72; P < .0001) and post-ACTH cortisol concentrations (r = 0.35; P = .02). The timing of HPA axis recovery of the dogs undergoing an alternate-day tapering dose was not different compared to dogs that did not (3.5 vs 3 days, P = .89). CONCLUSION AND CLINICAL IMPORTANCE Most dogs experienced HPA axis recovery within a few days after IAGC discontinuation. However, 2/20 dogs required >8 weeks.Palabras clave
Texto completo:
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Base de datos:
MEDLINE
Asunto principal:
Glucocorticoides
/
Sistema Hipotálamo-Hipofisario
Tipo de estudio:
Observational_studies
Idioma:
En
Revista:
J Vet Intern Med
/
J. vet. intern. med
/
Journal of veterinary internal medicine
Asunto de la revista:
MEDICINA INTERNA
/
MEDICINA VETERINARIA
Año:
2024
Tipo del documento:
Article