Swieteliacates S-U, phragmalin limonoids, from the leaves of Swietenia macrophylla.
Org Biomol Chem
; 22(11): 2182-2186, 2024 03 13.
Article
en En
| MEDLINE
| ID: mdl-38390690
ABSTRACT
Three novel phragmalin-type limonoids, swieteliacates S-U (1-3), were isolated from Swietenia macrophylla leaves, alongside four previously identified limonoids (4-7). The structures, encompassing absolute configurations, were delineated through 1D and 2D NMR analyses, high-resolution mass spectrometry (HR-MS), and NMR and ECD calculations. Swieteliacate S (1) is a distinctive cryptate comprising a tricyclo[4.2.110,30.11,4]decane fragment and an additional five-membered oxygen ring. Compounds 3 and 5 exhibited inhibition rates of 26.08 ± 2.26% and 15.42 ± 3.66%, respectively, on triglyceride (TG) production in Hep G2 cells at 40 µM.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Meliaceae
/
Limoninas
Idioma:
En
Revista:
Org Biomol Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2024
Tipo del documento:
Article