Correlation of serum level of squamous cell carcinoma antigen with severity of cutaneous psoriasis, assessed using the simplified psoriasis index.
Ann Dermatol Venereol
; 151(1): 103246, 2024 Mar.
Article
en En
| MEDLINE
| ID: mdl-38422600
ABSTRACT
BACKGROUND:
Squamous cell carcinoma antigen (SCCA) is a biomarker of disease progression in squamous cell carcinoma but also contributes to the pathogenesis of psoriasis. Eight previous studies have shown a correlation between psoriasis severity, assessed using the Psoriasis Assessment Severity Index or body surface area, and serum level of SCCA, mainly SCCA2, assessed by means of non-commercial tests. We examined the correlation between serum SCCA level, measured with a commercial kit, and psoriasis severity assessed using the Simplified Psoriasis Index (SPI).METHODS:
We conducted a prospective, non-interventional, single-centre study at the University Hospital of Tours over 18â¯months. The primary endpoint was same-day measurement of serum SCCA level and the psoriasis severity score on the professional version of the SPI (proSPI-s) at both baseline and follow-up. Secondary endpoints were same-day measurement of serum SCCA level and the proSPI psychosocial score (proSPI-p), proSPI treatment score, Dermatology Life Quality Index (DLQI), and inflammation parameters (C-reactive protein level, neutrophil-to-lymphocyte ratio).RESULTS:
We included 50 psoriasis patients. Serum SCCA level was correlated with the proSPI-s at baseline and follow-up (Spearman râ¯=â¯0.686 and râ¯=â¯0.674, pâ¯<â¯0.0001) for both. It was correlated with the proSPI-p and DLQI. Serum SCCA level was not correlated with either neutrophil-to-lymphocyte ratio (râ¯=â¯0.083) or C-reactive protein level (râ¯=â¯0.192).CONCLUSION:
This study is the first to correlate serum SCCA level with proSPI-s. Moreover, SCCA was measured using a widely available kit. SCCA may be used to assess the severity of psoriasis.Palabras clave
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Base de datos:
MEDLINE
Asunto principal:
Psoriasis
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Proteína C-Reactiva
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Serpinas
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Antígenos de Neoplasias
Idioma:
En
Revista:
Ann Dermatol Venereol
Año:
2024
Tipo del documento:
Article