Versatile roles of cysteine persulfides in tumor biology.
Curr Opin Chem Biol
; 79: 102440, 2024 04.
Article
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| MEDLINE
| ID: mdl-38422870
ABSTRACT
Rewiring the transsulfuration pathway is recognized as a rapid adaptive metabolic response to environmental conditions in cancer cells to support their increased cysteine demand and to produce Reactive Sulfur Species (RSS) including hydrogen sulfide (H2S) and cysteine persulfide. This can directly (via RSS) or indirectly (by supplying Cys) trigger chemical or enzyme catalyzed persulfidation on critical protein cysteine residues to protect them from oxidative damage and to orchestrate protein functions, and thereby contribute to cancer cell plasticity. In this review key aspects of persulfide-mediated biological processes are highlighted and critically discussed in relation to cancer cell survival, bioenergetics, proliferation as well as in tumor angiogenesis, adaptation to hypoxia and oxidative stress, and regulation of epithelial to mesenchymal transition.
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1
Base de datos:
MEDLINE
Asunto principal:
Cisteína
/
Disulfuros
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Transición Epitelial-Mesenquimal
Idioma:
En
Revista:
Curr Opin Chem Biol
Asunto de la revista:
BIOQUIMICA
Año:
2024
Tipo del documento:
Article