Preparation of copolymer 7-hydroxyethyl chrysin loaded PLGA nanoparticles and the in vitro release. / 7-ç¾ä¹åºç½æ¨ç´ èä¹³é
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Zhejiang Da Xue Xue Bao Yi Xue Ban
; 53(1): 116-125, 2024 Feb 05.
Article
en En, Zh
| MEDLINE
| ID: mdl-38426693
ABSTRACT
OBJECTIVES:
To prepare 7-hydroxyethyl chrysin (7-HEC) loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles and to detect the in vitro release.METHODS:
The 7-HEC/PLGA nanoparticles were prepared by emulsification solvent volatilization method. The particle size, polydispersity index (PDI), encapsulation rate, drug loading and zeta potential were measured. The prescription was optimized by single factor investigation combined with Box-Behnken response surface method. Mannitol was used as protectant to prepare lyophilized powder, and the optimal formulation was characterized and studied for the in vitro release.RESULTS:
The optimal formulation of 7-HEC/PLGA nanoparticles was as follows drug loading ratio of 2.12â¶20, oil-water volume ratio of 1â¶14.7, and 2.72% soybean phospholipid as emulsifier. With the optimal formulation, the average particle size of 7-HEC/PLGA nanoparticles was (240.28±0.96) nm, the PDI was 0.25±0.69, the encapsulation rate was (75.74±0.80)%, the drug loading capacity was (6.98±0.83)%, and the potentiostatic potential was (ï¼18.17±0.17) mV. The cumulative in vitro release reached more than 50% within 48 h.CONCLUSIONS:
The optimized formulation is stable and easy to operate. The prepared 7-HEC/PLGA nanoparticles have uniform particle size, high encapsulation rate and significantly higher dissolution rate than 7-HEC.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Ácido Poliglicólico
/
Flavonoides
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Nanopartículas
Idioma:
En
/
Zh
Revista:
Zhejiang Da Xue Xue Bao Yi Xue Ban
Asunto de la revista:
MEDICINA
Año:
2024
Tipo del documento:
Article