NRG1-ErbB4 signaling in the medial amygdala controls mating motivation in adult male mice.
Cell Rep
; 43(3): 113905, 2024 Mar 26.
Article
en En
| MEDLINE
| ID: mdl-38446660
ABSTRACT
Motivation-driven mating is a basic affair for the maintenance of species. However, the underlying molecular mechanisms that control mating motivation are not fully understood. Here, we report that NRG1-ErbB4 signaling in the medial amygdala (MeA) is pivotal in regulating mating motivation. NRG1 expression in the MeA negatively correlates with the mating motivation levels in adult male mice. Local injection and knockdown of MeA NRG1 reduce and promote mating motivation, respectively. Consistently, knockdown of MeA ErbB4, a major receptor for NRG1, and genetic inactivation of its kinase both promote mating motivation. ErbB4 deletion decreases neuronal excitability, whereas chemogenetic manipulations of ErbB4-positive neuronal activities bidirectionally modulate mating motivation. We also identify that the effects of NRG1-ErbB4 signaling on neuronal excitability and mating motivation rely on hyperpolarization-activated cyclic nucleotide-gated channel 3. This study reveals a critical molecular mechanism for regulating mating motivation in adult male mice.
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Motivación
Idioma:
En
Revista:
Cell Rep
/
Cell reports
Año:
2024
Tipo del documento:
Article