Harnessing the supremacy of MEG3 LncRNA to defeat gastrointestinal malignancies.
Pathol Res Pract
; 256: 155223, 2024 Apr.
Article
en En
| MEDLINE
| ID: mdl-38452587
ABSTRACT
Evidence suggests that long non-coding RNAs (lncRNAs) play a pivotal role in the carcinogenesis and progression of various human malignancies including gastrointestinal malignancies. This comprehensive review reports the functions and mechanisms of the lncRNA maternally expressed gene 3 (MEG3) involved in gastrointestinal malignancies. It summarizes its roles in mediating the regulation of cellular proliferation, apoptosis, migration, invasiveness, epithelial-to-mesenchymal transition, and drug resistance in several gastrointestinal cancers such as colorectal cancer, gall bladder cancer, pancreatic cancer, gastric cancer, esophageal cancer, cholangiocarcinoma, gastrointestinal stromal tumors and most importantly, hepatocellular carcinoma. In addition, the authors briefly highlight its implicated mechanistic role and interactions with different non-coding RNAs and oncogenic signaling cascades. This review presents the rationale for developing non coding RNA-based anticancer therapy via harnessing the power of MEG3 in gastrointestinal malignancies.
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Gástricas
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Neoplasias de los Conductos Biliares
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Carcinoma Hepatocelular
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ARN Largo no Codificante
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Neoplasias Hepáticas
Idioma:
En
Revista:
Pathol Res Pract
Año:
2024
Tipo del documento:
Article